Antiproteases as Therapeutics to Target Inflammation in Cystic Fibrosis~!2009-07-21~!2009-10-30~!2010-03-30~!
نویسندگان
چکیده
منابع مشابه
Antiproteases as Therapeutics to Target Inflammation in Cystic Fibrosis
Cystic Fibrosis (CF) is the most common fatal inherited disease of Caucasians, affecting about 1 in 3000 births. Patients with CF have a recessive mutation in the gene encoding the CF transmembrane conductance regulator (CFTR). CFTR is expressed in the epithelium of many organs throughout the exocrine system, however, inflammation and damage of the airways as a result of persistent progressive ...
متن کاملBiotechnologies and therapeutics: chromatin as a target.
As alterations in gene expression underlie a considerable proportion of human diseases, correcting such aberrant transcription in vivo is expected to provide therapeutic benefit to the patient. Attempts to control endogenous mammalian genes, however, face a significant obstacle in the form of chromatin. Aberrant gene repression can be alleviated by using small-molecule inhibitors that exert nuc...
متن کاملHow Can We Target Pulmonary Inflammation in Cystic Fibrosis?
With each year our enhanced understanding of the pathogenesis of cystic fibrosis (CF) is challenged by new discoveries related to the increasingly complex nature of this disorder. Originally described as a genetic disorder principally due to defective chloride ion conductance at epithelial surfaces and a predisposition to bacterial colonization have been moved into the category of an inflammato...
متن کاملraddis, 10-30-89 THEORY OF RADAR TARGET DISCRIMINATION
We give a direct application of probability theory to the problem of deciding which of a set of possible targets is present. The reliability of discrimination depends on the noise level, the background hash, the variation of echo with target aspect angles, the energy and shape of the transmitted pulse, and the number of pulses. The e ect of each of these variables is calculated and discussed, l...
متن کامل2012-07-03 Dissertation Submission
Later-life Effects of Mitochondrial DNA Damage During Development in the Whole Organism Model Caenorhabditis elegans by Maxwell C. K. Leung Environment Duke University Date:_______________________ Approved: ___________________________ Joel N. Meyer, Supervisor ___________________________ Shawn Ahmed ___________________________ Jonathan H. Freedman ___________________________ David E. Hinton An ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Open Respiratory Medicine Journal
سال: 2010
ISSN: 1874-3064
DOI: 10.2174/1874306401004020020